反应详情

A solution of 2,6-dichloro-5-methoxy-4-vinyl pyrimidine (50 g, 0.24 mol) in dichloromethane:methanol (4:1, 2 L) was cooled to −78° C. Ozone gas was bubbled therethrough for 5 h. The reaction was quenched with dimethyl sulfide (50 mL). The mixture was slowly warmed to room temperature and concentrated under reduced pressure at 40° C. to provide the title compound (50.5 g, 100%); HPLC (85% acetonitrile buffered with 0.1% v/v acetic acid).

1. customOzone gas was bubbled
2. customThe reaction was quenched with dimethyl sulfide (50 mL)
3. concentrationconcentrated under reduced pressure at 40° C.