(S)-(-)-N-Boc-prolinol → HCID 58984973, compound

HRID 923707Notes

Reaction equation

HRID 923707 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:14][C@@H:13]([O:15][CH3:16])[CH2:12][C@H:9]1[CH2:10][OH:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].C(OC(N1CCC[C@H]1CO)=O)(C)(C)C>>[C:1]([O:5][C:6]([N:8]1[CH2:14][C@@H:13]([O:15][CH3:16])[CH2:12][C@H:9]1[CH:10]=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 643448(S)-(-)-N-Boc-prolinolHCID 589850231,1-Dimethylethyl (2S,4S)-2-(hydroxymethyl)-4-methoxy-1-pyrrolidinecarboxylate

Product 1

HCID 58984973HCID 58984973, compound

Procedure

With the exception that N-t-butoxycarbonyl-cis-4-methoxy-L-prolinol, instead of N-t-butoxycarbonyl-L-prolinol, was used, the same procedure as in Preparation Example 1-1 was repeated to afford the title compound. 6.94 g (65%).

Workup

  1. customthe same procedure as in Preparation Example 1-1

Sources & evidence

ORD record
ord-a8efbec2b944404d93bc2a6fc174b1ba
Source dataset
uspto-grants-2016_03
Patent number
US09278996B2

Reaction notes

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