HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-(-)-N-Boc-prolinol → tert-Butyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-formylpyrrolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-(-)-N-Boc-prolinol | HCID 643448 | — |
| Reactant | tert-butyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate | HCID 11078078 | — |
| Product | tert-Butyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-formylpyrrolidine-1-carboxylate | HCID 10969557 | — |
Reaction Steps
With the exception that N-t-butoxycarbonyl-trans-4-(t-butyldimethylsilyl)oxy-L-prolinol, instead of N-t-butoxycarbonyl-L-prolinol, was used, the same procedure as in Preparation Example 1-1 was repeated to afford the title compound. 9.64 g (66%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278996B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-8ebbef6a26e14ae6ab0021e0611846c4 |
| Source note | uspto-grants-2016_03 |