(S)-(-)-N-Boc-prolinol → HCID 60068809, compound

HRID 923710Notes

Reaction equation

HRID 923710 reaction equation
[C:1]([O:5][C:6]([N:8]1[C@H:12]([CH2:13][OH:14])[CH2:11][S:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(OC(N1CCC[C@H]1CO)=O)(C)(C)C>>[CH:13]([C@H:12]1[CH2:11][S:10][CH2:9][N:8]1[C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])=[O:14]

Participants

3

Reactant 2

HCID 643448(S)-(-)-N-Boc-prolinolHCID 54275443HCID 54275443, compound

Product 1

HCID 60068809HCID 60068809, compound

Procedure

With the exception that (R)-t-butyl-4-(hydroxymethyl)thiazolidine-3-carboxylate, instead of N-t-butoxycarbonyl-L-prolinol, the same procedure as in Preparation Example 1-1 was repeated to afford the title compound. 9.21 g (44%).

Sources & evidence

ORD record
ord-fae20b02444b4c438fd44e20067a4c6a
Source dataset
uspto-grants-2016_03
Patent number
US09278996B2

Reaction notes

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