4-Bromoanisole → HCID 89666865, compound

Participants

Role	Name	HCID	Charge
Reactant	4-Bromoanisole	HCID 7730	—
Reactant	1-Bromo-3,5-difluorobenzene	HCID 136313	—
Reactant	(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamate	HCID 11806530	—
Reactant	N~2~-(tert-Butoxycarbonyl)-N-methoxy-N-methyl-D-alaninamide	HCID 23537239	—
Product	HCID 89666865	HCID 89666865	—

Reaction Steps

With the exception that (S)-t-butyl(1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamate and 1-bromo-3,5-difluorobenzene were used instead of (R)-t-butyl(1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamate and 4-methoxybromobenzene, respectively, the same procedure as in Preparation Example 5-5 was repeated to afford the title compound. 1.3 g (46%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09278996B2
Source dataset	uspto-grants-2016_03
ORD ID	ord-45dc5bbfc525438ab65805f27f8f954f
Source note	uspto-grants-2016_03