HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → H-Gln(Trt)-Thr-Leu
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | Thr-Leu | HCID 7021828 | — |
| Reactant | (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-[(triphenylmethyl)carbamoyl]butanoic acid | HCID 10919157 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | H-Gln(Trt)-Thr-Leu | HCID 131731099 | — |
Reaction Steps
In an RBF were mixed Fmoc-Gln(Trt)-OH (44.7 g, 73.2 mmol), BOP (40.4 g, 91.5 mmol) and 250 ml of DMF. The mixture was stirred for 2 min and then DIPEA (18.9 g, 146.4 mmol) was added. The resulting mixture was added in one portion to the pre-swollen H-Thr-Leu-Resin and the reaction mixture was stirred for 2.5 h, the Kaiser test was negative, then the reaction was considered to be complete and the reaction medium was removed via filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278997B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-bccc98b0463b4e9f830c0839490071ec |
| Source note | uspto-grants-2016_03 |