N-Methyl-3-nitro-5-(trifluoromethyl)pyridin-2-amine → N2-Methyl-5-(trifluoromethyl)pyridine-2,3-diamine

Participants

Reaction Steps

A mixture of N-methyl-(3-nitro-5-trifluoromethyl-pyridin-2-yl)-amine (6.93 g), 5% of palladium-carbon (0.69 g), and ethanol was stirred under about 1 atm of hydrogen at room temperature for 10 hours. The reaction mixture was filtered through Celite®, and then the filtrate was concentrated under reduced pressure to give 5.02 g of N2-methyl-5-trifluoromethylpyridin-2,3-diamine (Compound (1F)-1).

Provenance & Evidence