Methyl chloroformate → HCID 68091214, compound

HRID 923802Notes

Reaction equation

HRID 923802 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([NH2:10])[C:6]([NH2:9])=[N:7][CH:8]=1.Cl[C:14]([O:16][CH3:17])=[O:15]>N1C=CC=CC=1>[NH2:9][C:6]1[C:5]([NH:10][C:14](=[O:15])[O:16][CH3:17])=[CH:4][C:3]([C:2]([F:1])([F:11])[F:12])=[CH:8][N:7]=1

Participants

4

Reactant 2

HCID 6586Methyl chloroformateHCID 102144255-(Trifluoromethyl)pyridine-2,3-diamine

Product 1

HCID 68091214HCID 68091214, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a mixture of 5-trifluoromethylpyridin-2,3-diamine (1.2 g) and pyridine (20 ml), methyl chloroformate (0.63 ml) was added under ice-cooling. The mixture was heated to room temperature, stirred for 8 hours, and concentrated under reduced pressure. The resulting residue was subjected to silica gel column chromatography to give 628 mg of methyl (2-amino-5-trifluoromethylpyridin-3-yl)-carbamate.

Workup

  1. additionwas added under ice-
  2. temperaturecooling
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-23360a9ca3504b8c9174126dbbded0c1
Source dataset
uspto-grants-2016_03
Patent number
US09278983B2

Reaction notes

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