(2-Chloro-6-nitro-4-trifluoromethylphenyl)-methylamine → 3-Chloro-N2-methyl-5-(trifluoromethyl)-1,2-benzenediamine

HRID 923805Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 923805
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([N+:12]([O-])=O)[C:3]=1[NH:15][CH3:16].[H][H]>[Ni].C(O)C>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([NH2:12])[C:3]=1[NH:15][CH3:16]

Komponenten

5

Edukt 2

HCID 67981579(2-Chloro-6-nitro-4-trifluoromethylphenyl)-methylamineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 680910673-Chloro-N2-methyl-5-(trifluoromethyl)-1,2-benzenediamineAusbeute 90,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To a mixture of (2-chloro-6-nitro-4-trifluoromethylphenyl)-methylamine (3.70 g) and ethanol (60 ml), Raney® nickel (slurry in water, 0.5 ml) was added, and stirred under about 1 atm of hydrogen at room temperature for 1.5 hours. The reaction mixture was filtered. The filtrate was concentrated under reduced pressure. The resulting residue was subjected to silica gel column chromatography to give 2.95 g of 3-chloro-N2-methyl-5-trifluoromethylbenzene-1,2-diamine.

Aufarbeitung

  1. additionwas added
  2. filtrationThe reaction mixture was filtered
  3. concentrationThe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-184b5e0e8bd84e838c43c4ac89e72238
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09278983B2

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