1-Butanol → HCID 46843651, compound

HRID 923819Notes

Reaction equation

HRID 923819 reaction equation
[CH2:1]([P:3]([CH2:6][OH:7])(=[O:5])[OH:4])[CH3:2].[CH2:8](O)[CH2:9][CH2:10][CH3:11]>O>[CH2:1]([P:3]([CH2:6][OH:7])(=[O:4])[O:5][CH2:8][CH2:9][CH2:10][CH3:11])[CH3:2]

Participants

4

Reactant 2

HCID 2631-ButanolHCID 21555224HCID 21555224, compound

Product 1

HCID 46843651HCID 46843651, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

405.5 g of ethylhydroxymethylphosphinic acid (prepared according to example 1) are admixed with 1115 g of butanol and the water of condensation is removed with a water trap by boiling at atmospheric pressure. After the esterification has ended, the butanol is separated off in vacuo and the residue is vacuum distilled via a Vigreux column to obtain 392 g of n-butyl ethylhydroxymethylphosphinate in a 79% yield.

Workup

  1. customis removed with a water trap by boiling at atmospheric pressure
  2. customthe butanol is separated off in vacuo
  3. distillationdistilled via a Vigreux column

Sources & evidence

ORD record
ord-70bb28560ee74cc791c6d5505c085ab9
Source dataset
uspto-grants-2016_03
Patent number
US09279085B2

Reaction notes

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