2-(Trifluoromethyl)pyridine-5-boronic Acid → HCID 118195179, compound

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Example 28 using 5-bromo-6-(3-hydroxypyrrolidin-1-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 12.1) and (6-(trifluoromethyl)pyridin-3-yl)boronic acid to afford an off-white solid. UPLC-MS (condition 1) tR=2.77 min, m/z=513.0 [M+H]+, m/z=511.1 [M−H]−; 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.70-1.80 (m, 1H) 1.80-1.91 (m, 1H) 2.85 (d, J=11.49 Hz, 1H) 3.15-3.27 (m, 2H) 3.35-3.46 (m, 1H) 4.16-4.26 (m, 1H) 4.87 (d, J=3.42 Hz, 1H) 7.35 (d, J=8.56 Hz, 2H) 7.85 (d, J=9.05 Hz, 2H) 8.00 (d, J=8.07 Hz, 1H) 8.06-8.14 (m, 2H) 8.80 (d, J=2.20 Hz, 1H) 8.85 (d, J=1.71 Hz, 1H) 10.17 (s, 1H).

Provenance & Evidence