5-Methylpyridine-3-boronic acid → HCID 118195265, compound

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Example 36 using (R)-5-bromo-6-(3-hydroxypyrrolidin-1-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 35.1) and (5-methylpyridin-3-yl)boronic acid to afford a white solid. UPLC-MS (condition 1) tR=1.87 min, m/z=459.1 [M+H]+, m/z=457.2 [M−H]−; 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.66-1.79 (m, 1H) 1.85 (d, J=9.05 Hz, 1H) 2.39 (s, 3H) 2.88 (d, J=11.98 Hz, 1H) 3.15-3.30 (m, 2H) 3.37-3.49 (m, 1H) 4.15-4.25 (m, 0H) 4.83 (br. s, 0H) 7.35 (d, J=8.31 Hz, 2H) 7.67 (s, 1H) 7.85 (d, 2H) 8.02 (d, J=2.45 Hz, 1H) 8.39-8.49 (m, 2H) 8.77 (d, J=2.45 Hz, 1H) 10.15 (s, 1H).

Provenance & Evidence