(5-Fluoropyridin-3-yl)boronic acid → HCID 118195275, compound

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Example 36 using (R)-5-bromo-6-(3-hydroxypyrrolidin-1-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 35.1) and (5-fluoropyridin-3-yl)boronic acid to afford a white solid. UPLC-MS (condition 1) tR=2.39 min, m/z=463.1 [M+H]+, m/z=461.2 [M−H]−; 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.69-1.79 (m, 1H) 1.79-1.91 (m, 1H) 2.88 (d, J=11.00 Hz, 1H) 3.17-3.27 (m, 2H) 3.36-3.45 (m, 1H) 4.21 (br. s, 1H) 4.87 (br. s, 1H) 7.35 (d, J=8.56 Hz, 2H) 7.79-7.90 (m, 3H) 8.08 (d, J=2.20 Hz, 1H) 8.51 (s, 1H) 8.60 (d, J=2.69 Hz, 1H) 8.78 (d, J=2.45 Hz, 1H) 10.17 (s, 1H).

Provenance & Evidence