(6-Fluoropyridin-3-yl)boronic acid → HCID 118195313, compound

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Example 54 using (R)-5-bromo-6-(3-hydroxypyrrolidin-1-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 35.1) and (6-fluoropyridin-3-yl)boronic acid to afford a white solid. LC-MS (Condition 2) tR=1.91 min, m/z=463.2-464.2 [M+H]+, m/z=461 [M−H]−; 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.69-1.78 (m, 1H) 1.79-1.89 (m, 1H) 2.89 (d, J=11.49 Hz, 1H) 3.17-3.28 (m, 2H) 3.34-3.44 (m, 1H) 4.20 (s, 1H) 4.85 (s, 1H) 7.29 (dd, J=8.44, 2.57 Hz, 1H) 7.35 (d, J=8.80 Hz, 2H) 7.85 (d, J=9.29 Hz, 2H) 7.98-8.05 (m, 2H) 8.30 (d, J=1.96 Hz, 1H) 8.77 (d, J=2.20 Hz, 1H) 10.16 (s, 1H).

Provenance & Evidence