[3-(Hydroxymethyl)phenyl]boronic acid → HCID 89908439, compound

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Example 57 using (R)-5-bromo-6-(3-hydroxypyrrolidin-1-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 35.1) and (3-(hydroxymethyl)phenyl)boronic acid to afford a yellow foam. HPLC (Condition 4) tR=4.57 min, UPLC-MS (Condition 3) tR=0.99 min, m/z=474.4 [M+H]+; 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.62-1.73 (m, 1H) 1.80 (m, J=8.60 Hz, 1H) 2.85 (d, J=11.73 Hz, 1H) 3.12-3.26 (m, 2H) 3.34-3.47 (m, 1H) 4.09-4.19 (m, 1H) 4.55 (d, J=5.47 Hz, 2H) 4.80 (d, J=3.52 Hz, 1H) 5.24 (t, J=5.67 Hz, 1H) 7.22 (d, J=7.43 Hz, 1H) 7.27-7.43 (m, 5H) 7.79-7.90 (m, 2H) 7.94 (d, J=2.35 Hz, 1H) 8.71 (d, J=2.35 Hz, 1H) 10.16 (s, 1H).

Provenance & Evidence