[3-Fluoro-5-(methoxycarbonyl)phenyl]boronic acid → HCID 118198931, compound

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Example 35 using (R)-5-bromo-6-(3-hydroxypyrrolidin-1-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 35.1) and (3-fluoro-5-(methoxycarbonyl)phenyl)boronic acid to afford a white solid. UPLC-MS (Condition 3), tR=1.18 min, m/z=520.2 [M+H]+; 1H-NMR (400 MHz, DMSO-d6), δ ppm 1.67-1.75 (m, 1H) 1.77-1.89 (m, 1H) 2.81-2.90 (m, 1H) 3.13-3.27 (m, 2H) 3.33-3.45 (m, 1H) 3.88 (s, 3H) 4.13-4.20 (m, 1H) 4.82 (d, J=1.00 Hz, 1H) 7.33 (d, J=8.60 Hz, 2H) 7.54-7.63 (m, 1H) 7.65-7.73 (m, 1H) 7.74-7.79 (m, 1H) 7.84 (d, J=9.38 Hz, 2H) 8.03 (d, J=2.35 Hz, 1H) 8.75 (d, J=2.35 Hz, 1H) 10.17 (s, 1H).

Provenance & Evidence