HuagongsheHuagongshe Chemistry Print Report · For research reference only
Quinoxalin-6-ylboronic acid → (R)-6-(3-Hydroxypyrrolidin-1-yl)-5-(quinoxalin-6-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Quinoxalin-6-ylboronic acid | HCID 45073596 | — |
| Reactant | (R)-5-chloro-6-(3-hydroxypyrrolidin-1-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide | HCID 89907107 | — |
| Product | (R)-6-(3-Hydroxypyrrolidin-1-yl)-5-(quinoxalin-6-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide | HCID 89908316 | — |
Reaction Steps
The title compound was prepared in an analogous fashion to that described in Example 46 using (R)-5-chloro-6-(3-hydroxypyrrolidin-1-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 38.1) and quinoxalin-6-ylboronic acid. LC-MS (Condition 6) tR=1.64 min, m/z=496.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278981B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-ebe96521289d4fe7a893d9c5c7076057 |
| Source note | uspto-grants-2016_03 |