(Pyrimidin-5-yl)boronic acid → HCID 89908206, compound

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Example 54 using 5-bromo-6-(trans-3-hydroxy-4-methoxypyrrolidin-1-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 72.1) and pyrimidin-5-ylboronic acid to afford a white solid. UPLC-MS (condition 1) tR=2.16 min, m/z=476.0 [M+H]+, m/z=474.0 [M−H]−; 1H-NMR (400 MHz, DMSO-d6) δ ppm 2.95 (d, J=11.25 Hz, 1H) 3.14 (d, J=11.98 Hz, 1H) 3.23 (s, 3H) 3.28-3.35 (m, 1H) 3.46 (dd, J=11.98, 4.40 Hz, 1H) 3.61-3.65 (m, 1H) 4.08 (br. s, 1H) 5.19 (d, J=3.67 Hz, 1H) 7.36 (d, J=8.31 Hz, 2H) 7.85 (d, 2H) 8.12 (d, J=2.20 Hz, 1H) 8.79 (d, J=2.45 Hz, 1H) 8.89 (s, 2H) 9.21 (s, 1H) 10.19 (s, 1H).

Provenance & Evidence