HCID 69826798, compound → HCID 89907977, compound

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Stage 12.1 using 5-bromo-6-chloro-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 12.2) and Trans-4-methoxy-3-pyrrolidinol hydrochloride to afford a white amorphous solid. UPLC-MS (condition 1) tR=2.65 min, m/z=475.9-477.9 [M+H]+, m/z=474.0-475.9 [M−H]−; 1H-NMR (400 MHz, DMSO-d6) δ ppm 3.31 (s, 3H) 3.58 (d, J=11.49 Hz, 1H) 3.66 (d, J=12.23 Hz, 1H) 3.72-3.77 (m, 1H) 3.92 (dd, J=11.86, 4.28 Hz, 1H) 3.97 (dd, J=12.10, 4.28 Hz, 1H) 4.22 (br. s, 1H) 5.30 (d, J=3.18 Hz, 1H) 7.36 (d, J=8.31 Hz, 2H) 7.85 (d, J=9.29 Hz, 2H) 8.36 (d, J=2.20 Hz, 1H) 8.68 (d, J=2.20 Hz, 1H) 10.25 (s, 1H).

Provenance & Evidence