反应详情

The title compound was prepared in an analogous fashion to that described in Example 75 using (S)-5-bromo-6-(3-(hydroxymethyl)pyrrolidin-1-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 78.1) and (6-methylpyridin-3-yl)boronic acid to afford a white solid. UPLC-MS (condition 1) tR=1.80 min, m/z=473.1-474.1 [M+H]+, m/z=472.2-471.2 [M−H]−; 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.51-1.61 (m, 1H) 1.78-1.88 (m, 1H) 2.17-2.25 (m, 1H) 2.53 (s, 3H) 2.99 (dd, J=11.00, 6.85 Hz, 1H) 3.11-3.19 (m, 2H) 3.22-3.30 (m, 2H) 3.33-3.37 (m, 1H) 4.60 (t, J=4.89 Hz, 1H) 7.34 (dd, J=8.31, 3.42 Hz, 3H) 7.69 (dd, J=7.95, 2.32 Hz, 1H) 7.83-7.88 (m, 2H) 7.98 (d, J=2.45 Hz, 1H) 8.49 (d, J=2.20 Hz, 1H) 8.74 (d, J=2.45 Hz, 1H) 10.16 (s, 1H).

1. customto afford a white solid