(5-Fluoropyridin-3-yl)boronic acid → HCID 118195255, compound

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Example 86 using bromo-6-(trans-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 92.1) and (5-fluoropyridin-3-yl)boronic acid to afford a white solid. UPLC-MS (Condition 3) tR=0.93 min, m/z=493.2 [M+H], m/z=491.4 [M−H]+, m/z=537.4 [M+ formic acid-H]; 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.99-2.18 (m, 1H) 2.83-2.96 (m, 1H) 3.07-3.18 (m, 1H) 3.18-3.32 (m, 2H) 3.41-3.50 (m, 2H) 3.93-4.03 (m, 1H) 4.62-4.71 (m, 1H) 4.99 (d, J=4.27 Hz, 1H) 7.36 (d, J=9.03 Hz, 2H) 7.82-7.93 (m, 3H) 8.08 (d, J=2.38 Hz, 1H) 8.52 (d, J=1.63 Hz, 1H) 8.61 (d, J=2.63 Hz, 1H) 8.78 (d, J=2.38 Hz, 1H) 10.20 (s, 1H).

Provenance & Evidence