Isopropanol → HCID 118198934, compound

Participants

Reaction Steps

A mixture of 5-bromo-6-chloro-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 12.2, 0.5 g, 1.264 mmol), (R)-tert-butyl pyrrolidin-3-ylcarbamate (283 mg, 1.517 mmol), iPrOH (4 mL) and DIPEA (0.442 mL, 0.327 g, 2.53 mmol) were subjected to MW irradiation at 140° C. for 30 min. The vial was cooled to RT and the RM was added to water (100 mL) and the resulting precipitate was collected by filtration. The obtained solid was washed with water (50 mL) and dried to afford the title compound as an off-white powder. LC-MS (Condition 6) tR=1.47 min, m/z=488.9/490.9 [M+H—H2C═C(CH3)2], m/z=545/547.0 [M+H]+.

Provenance & Evidence