tert-Butyl {[(3R)-pyrrolidin-3-yl]methyl}carbamate → HCID 118198939, compound

HRID 923935Notes

Reaction equation

HRID 923935 reaction equation
[Br:1][C:2]1[C:3](Cl)=[N:4][CH:5]=[C:6]([CH:21]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17]([F:20])([F:19])[F:18])=[CH:12][CH:11]=1)=[O:8].[NH:23]1[CH2:27][CH2:26][C@@H:25]([CH2:28][NH:29][C:30](=[O:36])[O:31][C:32]([CH3:35])([CH3:34])[CH3:33])[CH2:24]1>>[Br:1][C:2]1[C:3]([N:23]2[CH2:27][CH2:26][C@@H:25]([CH2:28][NH:29][C:30](=[O:36])[O:31][C:32]([CH3:34])([CH3:33])[CH3:35])[CH2:24]2)=[N:4][CH:5]=[C:6]([C:7](=[O:8])[NH:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][C:17]([F:20])([F:19])[F:18])=[CH:12][CH:11]=2)[CH:21]=1

Participants

3

Reactant 2

HCID 1519427tert-Butyl {[(3R)-pyrrolidin-3-yl]methyl}carbamateHCID 867025955-bromo-6-chloro-N-(4-(trifluoromethoxy)phenyl)nicotinamide

Product 1

HCID 118198939HCID 118198939, compound

Procedure

The title compound was prepared in an analogous fashion to that described in Stage 93.1 using 5-bromo-6-chloro-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 12.2) and (R)-tert-butyl (pyrrolidin-3-ylmethyl)carbamate. LC-MS (Condition 6) tR=1.46 min, m/z=558.9 [M+H]+, m/z=581.0 [M+Na]+.

Sources & evidence

ORD record
ord-23e6ec459c6547288bc70abc245ec2c0
Source dataset
uspto-grants-2016_03
Patent number
US09278981B2

Reaction notes

Loading…