(6-Methoxypyridin-3-yl)boronic acid → HCID 118195123, compound

HRID 923938Notes

Reaction equation

HRID 923938 reaction equation
Br[C:2]1[C:3]([N:22]2[CH2:26][CH2:25][C@@H:24]([CH2:27][NH:28]C(=O)OC(C)(C)C)[CH2:23]2)=[N:4][CH:5]=[C:6]([C:8](=[O:21])[NH:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][C:17]([F:20])([F:19])[F:18])=[CH:12][CH:11]=2)[CH:7]=1.[CH3:36][O:37][C:38]1[N:43]=[CH:42][C:41](B(O)O)=[CH:40][CH:39]=1>>[NH2:28][CH2:27][C@@H:24]1[CH2:25][CH2:26][N:22]([C:3]2[C:2]([C:41]3[CH:42]=[N:43][C:38]([O:37][CH3:36])=[CH:39][CH:40]=3)=[CH:7][C:6]([C:8]([NH:9][C:10]3[CH:15]=[CH:14][C:13]([O:16][C:17]([F:19])([F:20])[F:18])=[CH:12][CH:11]=3)=[O:21])=[CH:5][N:4]=2)[CH2:23]1

Participants

3

Reactant 2

HCID 2734368(6-Methoxypyridin-3-yl)boronic acidHCID 118198939HCID 118198939, compound

Product 1

HCID 118195123HCID 118195123, compound

Procedure

The title compound was prepared in an analogous fashion to that described in Example 93 using (S)-tert-butyl ((1-(3-bromo-5-((4-(trifluoromethoxy)phenyl)carbamoyl)pyridin-2-yl)pyrrolidin-3-yl)methyl)carbamate (Stage 108.1) and (6-methoxypyridin-3-yl)boronic acid. LC-MS (Condition 6) tR=0.92 min, m/z=488.0 [M+H]+.

Sources & evidence

ORD record
ord-c75600cc5b6140029c39ca390f04684f
Source dataset
uspto-grants-2016_03
Patent number
US09278981B2

Reaction notes

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