(Pyrimidin-5-yl)boronic acid → HCID 89907864, compound

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Example 86 using 5-bromo-6-(2-oxa-6-azaspiro[3.4]octan-6-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 116.1) and pyrimidin-5-ylboronic acid to afford a white solid. UPLC-MS (condition 1) tR=2.35 min, m/z=472.0 [M+H]+, m/z=470.0 [M−H]−; 1H-NMR (400 MHz, DMSO-d6) δ ppm 2.00-2.15 (m, 2H) 3.11 (t, J=6.72 Hz, 2H) 3.44 (s, 2H) 4.41-4.45 (m, 2H) 4.45-4.50 (m, 2H) 7.36 (d, J=8.31 Hz, 2H) 7.85 (d, J=9.05 Hz, 2H) 8.11 (d, J=2.45 Hz, 1H) 8.79 (d, J=2.45 Hz, 1H) 8.90 (s, 2H) 9.20 (s, 1H) 10.19 (s, 1H).

Provenance & Evidence