2-Oxa-6-azaspiro[3.4]octane → HCID 118195257, compound

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Stage 12.1 using 5-bromo-6-chloro-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Example 35) and 2-oxa-6-azaspiro[3,4]octane to afford white needles. UPLC-MS (condition 1) tR=2.93 min, m/z=471.9/473.9 [M+H]+, m/z=469.9/471.9 [M−H]−; 1H-NMR (400 MHz, DMSO-d6) δ ppm 2.20 (t, J=6.85 Hz, 2H) 3.73 (t, J=6.97 Hz, 2H) 3.95 (s, 2H) 4.51 (d, J=5.87 Hz, 2H) 4.60 (d, J=5.87 Hz, 2H) 7.35 (d, J=8.31 Hz, 2H) 7.82-7.88 (m, 2H) 8.36 (d, J=2.20 Hz, 1H) 8.69 (d, J=1.96 Hz, 1H) 10.24 (s, 1H).

Provenance & Evidence