4-(Trifluoromethoxy)aniline → HCID 89906996, compound

HRID 923947Notes

Reaction equation

HRID 923947 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][C:3]=1[I:11].[F:12][C:13]([F:23])([F:22])[O:14][C:15]1[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:19][C:18]2[CH:20]=[CH:21][C:15]([O:14][C:13]([F:12])([F:22])[F:23])=[CH:16][CH:17]=2)=[O:8])=[CH:4][C:3]=1[I:11]

Participants

3

Reactant 2

HCID 6008484-(Trifluoromethoxy)anilineHCID 116670154-Bromo-3-iodobenzoic acid

Product 1

HCID 89906996HCID 89906996, compound

Procedure

The title compound was prepared in an analogous fashion to that described in Stage 1.2 using 4-bromo-3-iodobenzoic acid and 4-(trifluoromethoxy)aniline to afford a white solid. UPLC-MS (condition 1) tR=3.64 min, m/z=485.7 [M+H]+, m/z=483.8 [M−H]−; Br pattern. 1H-NMR (400 MHz, DMSO-d6) δ ppm 7.38 (d, J=8.3 Hz, 2H) 7.82-7.93 (m, 4H) 8.47 (d, J=1.7 Hz, 1H) 10.52 (s, 1H).

Workup

  1. customto afford a white solid

Sources & evidence

ORD record
ord-08f65f59000f4c1aa2e7c479a6552e6f
Source dataset
uspto-grants-2016_03
Patent number
US09278981B2

Reaction notes

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