3-Pyridinylboronic acid → HCID 118195097, compound

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Example 118 using 5-bromo-6-(3-hydroxypiperidin-1-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 118.1) and pyridin-3-ylboronic acid to afford a white solid. UPLC-MS (condition 1) tR=2.06 min, m/z=459.1-460.1 [M+H]+, m/z=457.2-458.2 [M−H]−; 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.20-1.38 (m, 2H) 1.53-1.61 (m, 1H) 1.79-1.86 (m, 1H) 2.59 (dd, J=12.23, 9.05 Hz, 1H) 2.69-2.78 (m, 1H) 3.35-3.41 (m, 1H) 3.43-3.50 (m, 1H) 3.56-3.62 (m, 1H) 4.73 (d, J=4.40 Hz, 1H) 7.37 (d, J=8.80 Hz, 2H) 7.50-7.54 (m, 1H) 7.86 (d, J=9.05 Hz, 2H) 8.02 (dt, J=8.01, 1.86 Hz, 1H) 8.11 (d, J=2.45 Hz, 1H) 8.57-8.61 (m, 1H) 8.77 (d, J=2.20 Hz, 1H) 8.81 (d, J=1.71 Hz, 1H) 10.30 (s, 1H).

Provenance & Evidence