2-Methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine → 6-(3-(Hydroxymethyl)azetidin-1-yl)-5-(2-methylpyrimidin-5-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Example 128 using 5-bromo-6-(3-(hydroxymethyl)azetidin-1-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 135.1) and 2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine. HPLC (Condition 4) tR=4.61 min, UPLC-MS (Condition 3) tR=0.95 min, m/z=460.3 [M+H]+; 1H-NMR (400 MHz, DMSO-d6) δ ppm 2.55-2.63 (m, 1H) 2.67 (s, 3H) 3.39-3.52 (m, 4H) 3.73 (t, J=8.60 Hz, 2H) 4.69 (t, J=5.28 Hz, 1H) 7.34 (d, J=8.99 Hz, 2H) 7.79-7.88 (m, 2H) 8.01 (d, J=2.35 Hz, 1H) 8.70-8.82 (m, 3H) 10.18 (s, 1H).

Provenance & Evidence