(Pyrimidin-5-yl)boronic acid → 6-(3-(2-Hydroxypropan-2-yl)azetidin-1-yl)-5-(pyrimidin-5-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide

関与物質

反応手順

The title compound was prepared in an analogous fashion to that described in Example 128 using 5-bromo-6-(3-(2-hydroxypropan-2-yl)azetidin-1-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 142.1) and pyrimidin-5-ylboronic acid to afford an off-white powder. HPLC (Condition 4) tR=4.88 min, UPLC-MS (Condition 7) m/z=474.2 [M+H]+; 1H-NMR (400 MHz, DMSO-d6) δ ppm 0.94 (s, 6H) 2.50-2.58 (m, 1H) 3.63 (d, J=7.43 Hz, 4H) 4.39 (s, 1H) 7.34 (d, J=8.99 Hz, 2H) 7.49-7.68 (m, 1H) 7.79-7.91 (m, 2H) 8.06 (dd, J=2.15, 0.98 Hz, 1H) 8.73-8.81 (m, 1H) 8.85-8.96 (m, 1H) 9.20 (d, J=0.78 Hz, 1H) 10.19 (s, 1H).

情報源と証拠