Morpholine → 5-Bromo-6-morpholino-N-(4-(trifluoromethoxy)phenyl)nicotinamide

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Stage 12.1 using 5-bromo-6-chloro-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 12.2) and morpholine to afford an off-white solid. UPLC-MS (Condition 3) tR=1.20 min, m/z=445.9 [M+H]+, m/z=443.9 [M−H]−; 1H-NMR (400 MHz, DMSO-d6) δ ppm 3.37-3.46 (m, 4H) 3.69-3.81 (m, 4H) 7.39 (d, J=8.78 Hz, 2H) 7.86 (d, J=9.16 Hz, 2H) 8.47 (d, J=2.13 Hz, 1H) 8.80 (d, J=2.13 Hz, 1H) 10.44 (s, 1H).

Provenance & Evidence