反应详情

The title compound was prepared in an analogous fashion to that described in Example 151 using 5-bromo-6-(ethyl(2-hydroxyethyl)amino)-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 156.1) and (5-fluoropyridin-3-yl)boronic acid to afford a white solid. UPLC-MS (Condition 3) tR=1.09 min, m/z=465.3 [M+H]+, m/z=463.4 [M−H]−; 1H-NMR (400 MHz, DMSO-d6) δ ppm 0.90 (t, J=7.03 Hz, 3H) 3.16 (q, J=7.03 Hz, 2H) 3.35-3.42 (m, 2H) 3.49 (br. s, 2H) 4.62 (br. s, 1H) 7.36 (d, J=8.41 Hz, 2H) 7.80-7.89 (m, 2H) 7.98 (m, J=2.70, 1.82 Hz, 1H) 8.08 (d, J=2.38 Hz, 1H) 8.60 (d, J=2.76 Hz, 1H) 8.64 (t, J=1.63 Hz, 1H) 8.76 (d, J=2.38 Hz, 1H) 10.26 (s, 1H).

1. customto afford a white solid