5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile → HCID 118195111, compound

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Example 151 using 5-bromo-6-(ethyl(2-hydroxyethyl)amino)-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 156.1) and 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile to afford a white solid. UPLC-MS (Condition 3) tR=1.05 min, m/z=472.2 [M+H]+, m/z=470.3 [M−H]−; 1H-NMR (400 MHz, DMSO-d6) δ ppm 0.90 (t, J=6.97 Hz, 3H) 3.14 (q, J=7.01 Hz, 2H) 3.32-3.41 (m, 2H) 3.49 (q, J=5.71 Hz, 2H) 4.62 (t, J=5.26 Hz, 1H) 7.36 (d, J=8.80 Hz, 2H) 7.77-7.92 (m, 2H) 8.10 (d, J=2.20 Hz, 1H) 8.54 (t, J=1.96 Hz, 1H) 8.78 (d, J=2.20 Hz, 1H) 9.04 (dd, J=5.50, 2.08 Hz, 2H) 10.25 (s, 1H).

Provenance & Evidence