(5-Fluoropyridin-3-yl)boronic acid → HCID 118195084, compound

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Example 151 using (R)-5-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)nicotinamide (Stage 171.1) and (5-fluoropyridin-3-yl)boronic acid to afford a white solid. UPLC-MS (Condition 3) tR=1.03 min, m/z=479.1 [M+H]+, m/z=523.0 [M+ formic acid-H]; 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.68-1.79 (m, 1H) 1.80-1.91 (m, 1H) 2.87 (d, J=11.17 Hz, 1H) 3.17-3.29 (m, 2H) 3.35-3.45 (m, 1H) 4.20 (br. s, 1H) 4.89 (d, J=2.51 Hz, 1H) 7.35 (d, J=9.16 Hz, 2H) 7.82-7.89 (m, 3H) 8.08 (d, J=2.38 Hz, 1H) 8.51 (t, J=1.63 Hz, 1H) 8.60 (d, J=2.76 Hz, 1H) 8.78 (d, J=2.38 Hz, 1H) 10.20 (s, 1H).

Provenance & Evidence