2-Fluoropyridine-3-boronic acid → HCID 118195383, compound

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Example 133 using (R)-5-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)nicotinamide (Stage 171.1) and (2-fluoropyridin-3-yl)boronic acid to afford a white solid. HPLC (Condition 4) tR=5.22 min, UPLC-MS (Condition 3) tR=1.07 min, m/z=479.3 [M+H]+; 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.63-1.76 (m, 1H) 1.78-1.88 (m, 1H) 2.84-2.97 (m, 1H) 3.15 (m, J=4.70 Hz, 2H) 3.31-3.43 (m, 1H) 4.14-4.24 (m, 1H) 4.86 (br. s, 1H) 7.32 (d, J=8.99 Hz, 2H) 7.42-7.54 (m, 1H) 7.76-7.89 (m, 2H) 8.00 (d, J=2.35 Hz, 1H) 8.03-8.13 (m, 1H) 8.28 (d, J=4.69 Hz, 1H) 8.78 (d, J=2.35 Hz, 1H) 10.15 (s, 1H).

Provenance & Evidence