HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3S)-3-Pyrrolidinemethanol → (S)-5-Bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-(hydroxymethyl)pyrrolidin-1-yl)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3S)-3-Pyrrolidinemethanol | HCID 7446911 | — |
| Reactant | 5-bromo-6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)nicotinamide | HCID 72546089 | — |
| Product | (S)-5-Bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-(hydroxymethyl)pyrrolidin-1-yl)nicotinamide | HCID 86702603 | — |
Reaction Steps
The title compound was prepared in an analogous fashion to that described in Stage 33.1 using 5-bromo-6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)nicotinamide (Stage 169.2) and (S)-1-pyrrolidin-3-yl-methanol to afford an off-white crystalline solid. HPLC (Condition 4) tR=5.82 min, UPLC-MS (Condition 3) tR=1.14 min, m/z=476.2/478.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278981B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-f165c6ac42c64531bb09eb89acbcd404 |
| Source note | uspto-grants-2016_03 |