HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Ethylamino)ethanol → 5-bromo-6-(ethyl(2-hydroxyethyl)amino)-N-(4-((trifluoromethyl)thio)phenyl)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Ethylamino)ethanol | HCID 8072 | — |
| Reactant | 5-bromo-6-chloro-N-(4-((trifluoromethyl)thio)phenyl)nicotinamide | HCID 86702605 | — |
| Product | 5-bromo-6-(ethyl(2-hydroxyethyl)amino)-N-(4-((trifluoromethyl)thio)phenyl)nicotinamide | HCID 89906420 | — |
Reaction Steps
The title compound was prepared in an analogous fashion to that described in Stage 33.1 using 5-bromo-6-chloro-N-(4-((trifluoromethyl)thio)phenyl)nicotinamide (Stage 185.2) and 2-ethylamino-ethanol to afford a white crystalline solid. (Reaction Time was 10 h). HPLC (Condition 4) tR=6.33 min, UPLC-MS (Condition 3) tR=1.25 min, m/z=466.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278981B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-bd2e7cc521f446db80c1114e33895e39 |
| Source note | uspto-grants-2016_03 |