(Pyrimidin-5-yl)boronic acid → HCID 89907668, compound

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Example 185 using (R)-5-bromo-N-(3-chloro-4-(trifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)nicotinamide (Stage 204.1) and pyrimidin-5-ylboronic acid to afford a white foam. HPLC (Condition 4) tR=5.17 min, UPLC-MS (Condition 3) tR=1.03 min, m/z=480.1 [M+H]+; 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.74 (m, J=3.90 Hz, 1H) 1.79-1.93 (m, 1H) 2.88 (d, J=11.34 Hz, 1H) 3.21 (m, J=11.10, 4.50 Hz, 2H) 3.37 (m, J=7.00 Hz, 1H) 4.11-4.25 (m, 1H) 4.87 (d, J=3.52 Hz, 1H) 7.55 (d, J=8.99 Hz, 1H) 7.72-7.86 (m, 1H) 8.10 (dd, J=15.84, 2.54 Hz, 2H) 8.74-8.81 (m, 1H) 8.88 (s, 2H) 9.19 (s, 1H) 10.27 (s, 1H).

Provenance & Evidence