HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-6-chloropyridine-3-carboxylic acid → 5-bromo-6-chloro-N-(3-fluoro-4-((trifluoromethyl)thio)phenyl)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-6-chloropyridine-3-carboxylic acid | HCID 285433 | — |
| Reactant | 3-Fluoro-4-[(trifluoromethyl)sulfanyl]aniline | HCID 21614381 | — |
| Product | 5-bromo-6-chloro-N-(3-fluoro-4-((trifluoromethyl)thio)phenyl)nicotinamide | HCID 86702611 | — |
Reaction Steps
The title compound was prepared in an analogous fashion to that described in Stage 185.2 using 5-bromo-6-chloro-nicotinic acid and 3-fluoro-4-trifluoromethylsulfanyl-aniline to afford a white crystalline solid. HPLC (Condition 4) tR=6.71 min, UPLC-MS (Condition 3) tR=1.34 min, m/z=429 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278981B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-3d019a23b4f44b138437cfd9615387b6 |
| Source note | uspto-grants-2016_03 |