(Pyrimidin-5-yl)boronic acid → HCID 118195182, compound

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Example 151 using (R)-5-chloro-6-(3-hydroxypyrrolidin-1-yl)-N-(4-((trifluoromethyl)sulfonyl)phenyl)nicotinamide (Stage 214.1) and pyrimidin-5-ylboronic acid to afford a solid. UPLC-MS (Condition 3), tR=0.92 min, m/z=−492.3; 1H-NMR (400 MHz, DMSO-d6), δ ppm 1.74 (br. s, 1H) 1.85 (br. s, 1H) 2.91 (d, J=10.95 Hz, 1H) 3.18-3.26 (m, 2H) 3.32-3.45 (m, 1H) 4.22 (br. s, 1H) 4.90 (d, J=3.52 Hz, 1H) 8.05-8.16 (m, 3H) 8.16-8.25 (m, 2H) 8.81-8.86 (m, 1H) 8.90 (s, 2H) 9.20 (s, 1H) 10.65 (s, 1H).

Provenance & Evidence