4-Aminophenyl trifluoromethyl sulphone → HCID 89906999, compound

HRID 924082Notes

Reaction equation

HRID 924082 reaction equation
[Br:1][C:2]1[C:3]([Cl:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[F:12][C:13]([F:25])([F:24])[S:14]([C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[CH:19][CH:18]=1)(=[O:16])=[O:15]>>[Br:1][C:2]1[C:3]([Cl:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([NH:21][C:20]1[CH:22]=[CH:23][C:17]([S:14]([C:13]([F:25])([F:12])[F:24])(=[O:16])=[O:15])=[CH:18][CH:19]=1)=[O:9]

Participants

3

Reactant 2

HCID 1363154-Aminophenyl trifluoromethyl sulphoneHCID 2854335-Bromo-6-chloropyridine-3-carboxylic acid

Product 1

HCID 89906999HCID 89906999, compound

Procedure

The title compound was prepared in an analogous fashion to that described in Stage 169.2 using 5-bromo-6-chloro-nicotinic acid and 4-trifluoromethanesulfonyl-aniline to afford a solid. UPLC-MS (Condition 3) tR=1.23 min, m/z=−441 [M+H]+.

Workup

  1. customto afford a solid

Sources & evidence

ORD record
ord-2ec48be6f5af4455bb40ccef5b817d78
Source dataset
uspto-grants-2016_03
Patent number
US09278981B2

Reaction notes

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