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HRID924084

反应详情

EQUATION

反应方程式

HRID 924084 的结构方程式

REACTANTS

反应物

2
结构：O[C@@H]1CCNC1
HCID2759337

(R)-3-Hydroxypyrrolidine

C4H9NO

结构：CC(F)(F)Oc1ccc(NC(=O)c2cnc(Cl)c(Br)c2)cc1
HCID86702629

未命名化合物

PRODUCTS

生成物

1
结构：CC(F)(F)Oc1ccc(NC(=O)c2cnc(N3CC[C@@H](O)C3)c(Br)c2)cc1
HCID86702628

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in an analogous fashion to that described in Stage 33.1 using 5-bromo-6-chloro-N-(4-(1,1-difluoroethoxy)phenyl)nicotinamide (Stage 215.2) and (R)-pyrrolidin-3-ol to afford a white solid. HPLC (Condition 4) tR=5.11 min, UPLC-MS (Condition 3) tR=1.02 min, m/z=440.3 [M−H]−.

WORKUP

后处理

  1. customto afford a white solid