5-Bromo-6-chloropyridine-3-carboxylic acid → HCID 89906587, compound

HRID 924101Notes

Reaction equation

HRID 924101 reaction equation
[Br:1][C:2]1[C:3]([Cl:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[F:12][C:13]([F:24])([F:23])[S:14]([C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][CH:17]=1)=[O:15]>>[Br:1][C:2]1[C:3]([Cl:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([NH:20][C:19]1[CH:21]=[CH:22][C:16]([S:14]([C:13]([F:24])([F:12])[F:23])=[O:15])=[CH:17][CH:18]=1)=[O:9]

Participants

3

Reactant 2

HCID 2854335-Bromo-6-chloropyridine-3-carboxylic acidHCID 2354794Benzenamine, 4-[(trifluoromethyl)sulfinyl]-

Product 1

HCID 89906587HCID 89906587, compound

Procedure

The title compound was prepared in an analogous fashion to that described in Stage 169.2 using 5-bromo-6-chloro-nicotinic acid and 4-(trifluoromethylsulfinyl)aniline To afford an off-white crystalline solid. HPLC (Condition 4) tR=5.59 min, UPLC-MS (Condition 3) tR=1.10 min, m/z=425 [M−H]−.

Workup

  1. customTo afford an off-white crystalline solid

Sources & evidence

ORD record
ord-6c826f98668948f798d1fa35d5644ff2
Source dataset
uspto-grants-2016_03
Patent number
US09278981B2

Reaction notes

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