1,4-Dideoxy-1,4-iminothreitol → 3-Bromo-N-(4-(chlorodifluoromethoxy)phenyl)-4-((3 S,4S)-3,4-dihydroxypyrrolidin-1-yl)benzamide

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Stage 243.1 (20 h at 90° C.+3 h at 105° C.) using 3-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-4-fluorobenzamide and (3S,4S)-pyrrolidine-3,4-diol to afford a white amorphous solid. UPLC-MS (Condition 3) tR=1.01 min, m/z=476.8 [M+H]+.

Provenance & Evidence