(Pyrimidin-5-yl)boronic acid → HCID 118195338, compound

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Example 169 using (R)-5-bromo-6-(3-hydroxypyrrolidin-1-yl)-N-(6-((trifluoromethyl)thio)pyridin-3-yl)nicotinamide (Stage 279.1) and pyrimidin-5-ylboronic acid to afford a white resinous powder. HPLC (Condition 4) tR=4.41 min, UPLC-MS (Condition 3) tR=0.83 min, m/z=463.2 [M+H]+; 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.68-1.93 (m, 2H) 2.91 (d, J=11.34 Hz, 1H) 3.20-3.44 (m, 3H) 4.22 (br. s, 1H) 4.90 (d, J=3.52 Hz, 1H) 7.81 (d, J=8.60 Hz, 1H) 8.07-8.16 (m, 1H) 8.29-8.38 (m, 1H) 8.80-8.85 (m, 1H) 8.90 (s, 2H) 8.95-9.03 (m, 1H) 9.17-9.24 (m, 1H) 10.44 (s, 1H).

Provenance & Evidence