Potassium Carbonate → 6-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-5-(pyrimidin-5-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-chloro-5-(pyrimidin-5-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 223.1, 100 mg, 0.253 mmol) in DMF (2 mL) were added K2CO3 (105 mg, 0.760 mmol) and tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate (81 mg, 0.380 mmol). The RM was stirred at 110° C. for 4 h and then at 130° C. for 5 h. After removal of solvent under reduced pressure, the crude intermediate was treated with a mixture of TFA/DCM (1 mL/2 mL) at RT for 5 h. The solvent was evaporated off under reduced pressure to afford 6-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-5-(pyrimidin-5-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide, a portion of which (100 mg, 0.213 mmol) was dissolved in anhydrous THF (2 mL) and was treated with KOtBu (71.6 mg, 0.638 mmol) and 2-bromoethanol (0.1 mL, 1.435 mmol). The RM was stirred at 70° C. overnight, the solvent was evaporated off under reduced pressure and the crude material was purified by preparative HPLC. The compound was lyophilized in water/MeCN to afford the title product. UPLC-MS (Condition 3), tR=0.77 min, m/z=515.2 [M+H]+.

Provenance & Evidence