反应详情

The title compound was prepared in an analogous fashion to that described in Example 284 using 2-chloro-5′-fluoro-N-(4-(trifluoromethoxy)phenyl)-[3,3′-bipyridine]-5-carboxamide (Stage 236.1) and trans-4-methoxypyrrolidin-3-amine dihydrochloride (Stage 284.1, 20 h at 80° C. then 24 h at 100° C.). HPLC (Condition 10) tR=5.97 min, UPLC-MS (Condition 3) tR=0.83 min, m/z=492.2 [M+H]+; 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.62 (br. s, 2H) 2.82-2.90 (m, 1H) 3.02-3.11 (m, 1H) 3.21 (s, 3H) 3.26-3.34 (m, 2H) 3.47-3.57 (m, 2H) 7.35 (d, J=8.99 Hz, 2H) 7.85 (m, J=9.00 Hz, 3H) 8.08 (d, J=2.35 Hz, 1H) 8.51 (s, 1H) 8.60 (d, J=2.74 Hz, 1H) 8.77 (d, J=1.95 Hz, 1H) 10.17 (s, 1H).

1. customStage 284.1, 20 h
2. customat 80° C.
3. custom24 h
4. customat 100° C.