2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile → HCID 118195146, compound

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Example 298 using (R)-5-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)nicotinamide (Stage 171.1) and 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile to afford an off-white powder. UPLC-MS (Condition 11), tR=1.13 min, m/z=516.2/518.2 [M+H]+; 1H-NMR (600 MHz, DMSO-d6) δ ppm 1.67-1.78 (m, 1H) 1.79-1.93 (m, 1H) 2.90 (d, J=11.29 Hz, 1H) 3.19-3.29 (m, 2H) 3.35-3.43 (m, 1H) 4.06 (s, 3H) 4.21 (br. s, 1H) 4.90 (br. s, 1H) 7.33 (d, J=8.66 Hz, 2H) 7.85 (d, J=8.85 Hz, 2H) 8.02 (d, J=1.88 Hz, 1H) 8.35 (s, 1H) 8.50 (s, 1H) 8.77 (d, J=1.88 Hz, 1H) 10.18 (s, 1H).

Provenance & Evidence