1-(5-Chloro-2-isopropylphenyl)thiourea → (1Z)-1-[3-(5-chloro-2-propan-2-ylphenyl)-4-oxo-1,3-thiazolidin-2-ylidene]-3-[2-[4-[1-[4-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl]phenyl]ethyl]urea

Participants

Role	Name	HCID	Charge
Reactant	1-(5-Chloro-2-isopropylphenyl)thiourea	HCID 90412442	—
Reactant	3-(4-(1-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)propanoyl azide 3-(4-(2-isocyanatoethyl)phenyl)-1-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazole	HCID 131732837	—
Product	(1Z)-1-[3-(5-chloro-2-propan-2-ylphenyl)-4-oxo-1,3-thiazolidin-2-ylidene]-3-[2-[4-[1-[4-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl]phenyl]ethyl]urea	HCID 90411950	—

Reaction Steps

The title compound was prepared as described in Example 35 using 3-(4-(1-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)propanoyl azide/3-(4-(2-isocyanatoethyl)phenyl)-1-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazole (C35b) and 1-(5-chloro-2-isopropylphenyl)thiourea (CB32) at a temperature of 60° C., isolated as a clear oil (0.019 g, 12%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09278964B2
Source dataset	uspto-grants-2016_03
ORD ID	ord-b5f77e997b714954b176d103344169de
Source note	uspto-grants-2016_03