1-(4-Fluoro-2-isopropylphenyl)thiourea → HCID 90404309, compound

HRID 924206Notes

Reaction equation

HRID 924206 reaction equation
FC(F)(F)[O:3][C:4]1C=CC(N2C=NC(C3C=CC(C(CC)CC(N=[N+]=[N-])=O)=CC=3)=N2)=C[CH:5]=1.[N:32]([CH2:35][CH:36]([C:39]1[CH:44]=[CH:43][C:42]([C:45]2[N:49]=[CH:48][N:47]([C:50]3[CH:55]=[CH:54][C:53]([O:56][C:57]([F:60])([F:59])[F:58])=[CH:52][CH:51]=3)[N:46]=2)=[CH:41][CH:40]=1)[CH2:37][CH3:38])=[C:33]=[O:34].[F:61][C:62]1[CH:67]=[CH:66][C:65]([NH:68][C:69]([NH2:71])=[S:70])=[C:64]([CH:72]([CH3:74])[CH3:73])[CH:63]=1>>[F:61][C:62]1[CH:67]=[CH:66][C:65]([N:68]2[C:4](=[O:3])[CH2:5][S:70]/[C:69]/2=[N:71]\[C:33]([NH:32][CH2:35][CH:36]([C:39]2[CH:40]=[CH:41][C:42]([C:45]3[N:49]=[CH:48][N:47]([C:50]4[CH:51]=[CH:52][C:53]([O:56][C:57]([F:59])([F:58])[F:60])=[CH:54][CH:55]=4)[N:46]=3)=[CH:43][CH:44]=2)[CH2:37][CH3:38])=[O:34])=[C:64]([CH:72]([CH3:74])[CH3:73])[CH:63]=1

Participants

3

Reactant 2

HCID 893732451-(4-Fluoro-2-isopropylphenyl)thioureaHCID 904187603-(4-(1-(4-(trifluoromethoxy)phenyl)-1 H-1,2,4-triazol-3-yl)phenyl)pentanoyl azide 3-(4-(1-isocyanatobutan-2-yl)phenyl)-1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole

Product 1

HCID 90404309HCID 90404309, compound

Procedure

The title compound was prepared from 3-(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)pentanoyl azide/3-(4-(1-isocyanatobutan-2-yl)phenyl)-1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole (C42a) and 1-(4-fluoro-2-isopropylphenyl)thiourea and isolated as a brown foam (0.072 g, 30%).

Sources & evidence

ORD record
ord-b3bf245901f745238894c15b722486c9
Source dataset
uspto-grants-2016_03
Patent number
US09278964B2

Reaction notes

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